Linking neuronal brain activity to the glucose metabolism
نویسندگان
چکیده
منابع مشابه
Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity.
To determine the relationship between cerebral Glc metabolism and glutamatergic neuronal function, we used 13C NMR spectroscopy to measure, simultaneously, the rates of the tricarboxylic acid cycle and Gln synthesis in the rat cortex in vivo. From these measurements, we calculated the rates of oxidative Glc metabolism and glutamate-neurotransmitter cycling between neurons and astrocytes (a quan...
متن کاملNpas4: Linking Neuronal Activity to Memory.
Immediate-early genes (IEGs) are rapidly activated after sensory and behavioral experience and are believed to be crucial for converting experience into long-term memory. Neuronal PAS domain protein 4 (Npas4), a recently discovered IEG, has several characteristics that make it likely to be a particularly important molecular link between neuronal activity and memory: it is among the most rapidly...
متن کاملAdenosine: front and center in linking nutrition and metabolism to neuronal activity.
Many individuals with epilepsy benefit from consuming a ketogenic diet, which is similar to the more commonly known Atkins diet. The underlying molecular reason for this has not been determined. However, in this issue of the JCI, Masino et al. have elucidated the mechanism responsible for the antiepileptic effects of the ketogenic diet in mice. The diet is shown to decrease expression of the en...
متن کاملBoosting brain glucose metabolism to fight neurodegeneration?
Alzheimer's disease (AD) is the main cause of dementia in the elderly population with increasing prevalence. Despite the huge efforts invested in AD research, no therapeutic breakthrough has been witnessed yet. Likely, novel approaches and sweeping ideas will be necessary to effectively treat AD. Nevertheless, the earlier the disease is detected the more efficacious the therapy is. Early detect...
متن کاملNeuronal LRP1 regulates glucose metabolism and insulin signaling in the brain.
Alzheimer's disease (AD) is a neurological disorder characterized by profound memory loss and progressive dementia. Accumulating evidence suggests that Type 2 diabetes mellitus, a metabolic disorder characterized by insulin resistance and glucose intolerance, significantly increases the risk for developing AD. Whereas amyloid-β (Aβ) deposition and neurofibrillary tangles are major histological ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Theoretical Biology and Medical Modelling
سال: 2013
ISSN: 1742-4682
DOI: 10.1186/1742-4682-10-50